Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis.

ABSTRACT:

Background

Individuals with type 1 diabetes (T1D) generally have normal or even higher HDL (high-density lipoprotein)-cholesterol levels than people without diabetes yet are at increased risk for atherosclerotic cardiovascular disease (CVD). Human HDL is a complex mixture of particles that can vary in cholesterol content by >2-fold. To investigate if specific HDL subspecies contribute to the increased atherosclerosis associated with T1D, we created mouse models of T1D that exhibit human-like HDL subspecies. We also measured HDL subspecies and their association with incident CVD in a cohort of people with T1D.

Methods

We generated LDL receptor-deficient (Ldlr^-/-) mouse models of T1D expressing human APOA1 (apolipoprotein A1). Ldlr^-/-

SUBMITTER: Kothari V 

PROVIDER: S-EPMC11223987 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature