Cell shape sensing licenses dendritic cells for homeostatic migration to lymph nodes.

ABSTRACT: Immune cells experience large cell shape changes during environmental patrolling because of the physical constraints that they encounter while migrating through tissues. These cells can adapt to such deformation events using dedicated shape-sensing pathways. However, how shape sensing affects immune cell function is mostly unknown. Here, we identify a shape-sensing mechanism that increases the expression of the chemokine receptor CCR7 and guides dendritic cell migration from peripheral tissues to lymph nodes at steady state. This mechanism relies on the lipid metabolism enzyme cPLA₂, requires nuclear envelope tensioning and is finely tuned by the ARP2/3 actin nucleation complex. We also show that this shape-sensing axis reprograms dendritic cell transcription by activating an IK

SUBMITTER: Alraies Z 

PROVIDER: S-EPMC11224020 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature