Validation of cardiac image-derived input functions for functional PET quantification.

ABSTRACT:

Purpose

Functional PET (fPET) is a novel technique for studying dynamic changes in brain metabolism and neurotransmitter signaling. Accurate quantification of fPET relies on measuring the arterial input function (AIF), traditionally achieved through invasive arterial blood sampling. While non-invasive image-derived input functions (IDIF) offer an alternative, they suffer from limited spatial resolution and field of view. To overcome these issues, we developed and validated a scan protocol for brain fPET utilizing cardiac IDIF, aiming to mitigate known IDIF limitations.

Methods

Twenty healthy individuals underwent fPET/MR scans using [¹⁸F]FDG or 6-[¹⁸F]FDOPA, utilizing bed motion shuttling to capture cardiac IDIF and brain task-induced changes. Arterial

SUBMITTER: Reed MB 

PROVIDER: S-EPMC11224076 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature