Comparison of discovery rates and prognostic utility of [⁶⁸Ga]Ga-PSMA-11 PET/CT and circulating tumor DNA in prostate cancer-a cross-sectional study.

ABSTRACT:

Background

Circulating-tumor DNA (ctDNA) and prostate-specific membrane antigen (PSMA) ligand positron-emission tomography (PET) enable minimal-invasive prostate cancer (PCa) detection and survival prognostication. The present study aims to compare their tumor discovery abilities and prognostic values.

Methods

One hundred thirty men with confirmed PCa (70.5 ± 8.0 years) who underwent [⁶⁸Ga]Ga-PSMA-11 PET/CT (184.8 ± 19.7 MBq) imaging and plasma sample collection (March 2019-August 2021) were included. Plasma-extracted cell-free DNA was subjected to whole-genome-based ctDNA analysis. PSMA-positive tumor lesions were delineated and their quantitative parameters extracted. ctDNA and PSMA PET/CT discovery rates were compared, and the prognostic value for overall survi

SUBMITTER: Kluge K 

PROVIDER: S-EPMC11224100 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature