Synthesis and preclinical evaluation of novel ¹⁸F-vancomycin-based tracers for the detection of bacterial infections using positron emission tomography.

ABSTRACT:

Introduction

Bacterial infections are a major problem in medicine, and the rapid and accurate detection of such infections is essential for optimal patient outcome. Bacterial infections can be diagnosed by nuclear imaging, but most currently available modalities are unable to discriminate infection from sterile inflammation. Bacteria-targeted positron emission tomography (PET) tracers have the potential to overcome this hurdle. In the present study, we compared three ¹⁸F-labelled PET tracers based on the clinically applied antibiotic vancomycin for targeted imaging of Gram-positive bacteria.

Methods

[¹⁸F]FB-NHS and [¹⁸F]BODIPY-FL-NHS were conjugated to vancomycin. The resulting conjugates, together with our previously developed [¹⁸

SUBMITTER: Spoelstra GB 

PROVIDER: S-EPMC11224109 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature