Persistent Frustration-Induced Reconfigurations of Brain Networks Predict Individual Differences in Irritability.

ABSTRACT:

Objective

Aberrant responses to frustration are central mechanisms of pediatric irritability, which is a common reason for psychiatric consultation and a risk factor for affective disorders and suicidality. This pilot study aimed to characterize brain network configuration during and after frustration and test whether characteristics of networks formed during or after frustration relate to irritability.

Method

During functional magnetic resonance imaging, a transdiagnostic sample enriched for irritability (N = 66, mean age = 14.0 years, 50% female participants) completed a frustration-induction task flanked by pretask and posttask resting-state scans. We first tested whether and how the organization of brain regions (ie, nodes) into networks (ie, modules) changes during and

SUBMITTER: Linke JO 

PROVIDER: S-EPMC11224120 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature