Genetic causality and metabolite pathway identifying the relationship of blood metabolites and psoriasis.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory disease that causes significant disability. However, little is known about the underlying metabolic mechanisms of psoriasis. Our study aims to investigate the causality of 975 blood metabolites with the risk of psoriasis.

Materials and methods

We mainly applied genetic analysis to explore the possible associations between 975 blood metabolites and psoriasis. The inverse variance weighted (IVW) method was used as the primary analysis to assess the possible association of blood metabolites with psoriasis. Moreover, generalized summary-data-based Mendelian randomization (GSMR) was used as a supplementary analysis. In addition, linkage disequilibrium score regression (LDSC) was used to investigate their genetic correction further. M

SUBMITTER: Wang Z 

PROVIDER: S-EPMC11224122 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature