Genetic association between asthma and alopecia areata: A two-sample Mendelian randomization study.

ABSTRACT:

Background

Many patients with asthma experience alopecia areata (AA) in their lives. However, it is unclear whether asthma causes or results from AA. Our objective was to investigate the genetic causal relationship between asthma and AA.

Methods

Two-sample Mendelian randomization (MR) was used to assess the causal relationship between asthma and AA based on the largest publicly available genome-wide association study summary statistics. Androgenetic alopecia (AGA) and cicatricial alopecia (CA) were chosen as the control groups for AA. The main estimates were obtained using inverse variance weighting meta-analysis (IVW), Mendelian randomization-Egger (MR-Egger), maximum likelihood estimation, and the weighted median. Sensitivity analyses were conducted using Cochran's Q test,

SUBMITTER: Du W 

PROVIDER: S-EPMC11224124 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature