CD300LF⁺ microglia impede the neuroinflammation following traumatic brain injury by inhibiting STING pathway.

ABSTRACT:

Introduction

The diversity in microglial phenotypes and functions following traumatic brain injury (TBI) is poorly characterized. The aim of this study was to explore precise targets for improving the prognosis of TBI patients from a microglial perspective.

Objectives

To assess whether the prognosis of TBI can be improved by modulating microglia function.

Results

In CD300LF-deficient mice, we observed an increase in glial cell proliferation, more extensive neuronal loss, and worsened neurological function post-TBI. Transcriptomic comparisons between CD300LF-positive and CD300LF-negative microglia illuminated that the neuroprotective role of CD300LF is principally mediated by the inhibition of the STING signaling pathway. In addition, this protective effect can be augm

SUBMITTER: Lu Z 

PROVIDER: S-EPMC11224125 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature