The causal effect of atopic dermatitis on lung cancer: A Mendelian randomization study.

ABSTRACT:

Background

Growing evidence has shown that atopic dermatitis (AD) may decrease lung cancer (LC) risk. However, the causality between the two diseases is inconsistent and controversial. Therefore, we explored the causal relationship between AD and different histological subtypes of LC by using the Mendelian randomization (MR) method.

Materials and methods

We conducted the MR study based on summary statistics from the genome-wide association studies (GWAS) of AD (10,788 cases and 30,047 controls) and LC (29,266 cases and 56,450 controls). Instrumental variables (IVs) were obtained after removing SNPs associated with potential confounders. We employed inverse-variance weighted (IVW), MR-Egger, and weighted median methods to pool estimates, and performed a comprehensive sensitiv

SUBMITTER: Huang P 

PROVIDER: S-EPMC11224128 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature