Leveraging genetics to investigate causal effects of immune cell phenotypes in periodontitis: a mendelian randomization study.

ABSTRACT:

Introduction

Immune cells are dynamic in the inflammatory environment and play a key role in eradicating periodontal pathogens, modulating immune responses, and instigating tissue destruction. Identifying specific immune cell phenotypes associated with periodontitis risk is essential for targeted immunotherapeutic interventions. However, the role of certain specific immune cell phenotypes in the development of periodontitis is unknown. Mendelian randomization offers a novel approach to reveal causality and address potential confounding factors through genetic instruments.

Methods

This two-sample Mendelian randomization study assessed the causal relationship between 731 immune cell phenotypes and periodontitis using the inverse variance weighting method with the GWAS catalog

SUBMITTER: Bai Y 

PROVIDER: S-EPMC11224148 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature