Recruitment-to-inflation ratio reflects the impact of peep on dynamic lung strain in a highly recruitable model of ARDS.

ABSTRACT:

Background

The recruitment-to-inflation ratio (R/I) has been recently proposed to bedside assess response to PEEP. The impact of PEEP on ventilator-induced lung injury depends on the extent of dynamic strain reduction. We hypothesized that R/I may reflect the potential for lung recruitment (i.e. recruitability) and, consequently, estimate the impact of PEEP on dynamic lung strain, both assessed through computed tomography scan.

Methods

Fourteen lung-damaged pigs (lipopolysaccharide infusion) underwent ventilation at low (5 cmH₂O) and high PEEP (i.e., PEEP generating a plateau pressure of 28-30 cmH₂O). R/I was measured through a one-breath derecruitment maneuver from high to low PEEP. PEEP-induced changes in dynamic lung strain, difference in nonaerated

SUBMITTER: Murgolo F 

PROVIDER: S-EPMC11224186 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature