Pharmacokinetic and molecular docking studies to pyrimidine drug using Mn₃O₄ nanoparticles to explore potential anti-Alzheimer activity.

ABSTRACT: Alzheimer disease (AD) is the cause of dementia and accounts for 60-80% cases. Tumor Necrosis Factor-alpha (TNF-α) is a multifunctional cytokine that provides resistance to infections, inflammation, and cancer. It developed as a prospective therapeutic target against multiple autoimmune and inflammatory disorders. Cholinergic insufficiency is linked to Alzheimer's disease, and several cholinesterase inhibitors have been created to treat it, including naturally produced inhibitors, synthetic analogs, and hybrids. In the current study, we tried to prepared compounds may also support the discovery and development of novel therapeutic and preventative drugs for Alzheimer's using manganese tetroxide nanoparticles (Mn₃O₄-NPs) as a catalyst to generate compounds with excelle

SUBMITTER: Shehab WS 

PROVIDER: S-EPMC11224222 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature