Relationship between Sjogren's syndrome and gastroesophageal reflux: A bidirectional Mendelian randomization study.

ABSTRACT: The clinical incidence of sjogren's syndrome combined with gastroesophageal reflux disease is high. Existing observational studies have shown inconsistent results in the association between gastroesophageal reflux disease (GERD) and Sjogren's syndrome (SS).We observed that the symptoms of SS patients also improved after receiving GERD-related treatment. Therefore, we aimed to investigate the relationship between GERD and SS through a bidirectional two-sample Mendelian randomization (MR) study. Independent SNPs associated with GERD and SS were selected from a genome-wide association study (GWAS) as instrumental variables to conduct a bidirectional two-sample Mendelian analysis of GERD and SS. Genetic data were obtained from two databases for the following two outcomes: Gastroesophageal refl

SUBMITTER: Liu J 

PROVIDER: S-EPMC11224283 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature