Identifying novel proteins for suicide attempt by integrating proteomes from brain and blood with genome-wide association data.

ABSTRACT: Genome-wide association studies (GWASs) have identified risk loci for suicide attempt (SA), but deciphering how they confer risk for SA remains largely unknown. This study aims to identify the key proteins and gain insights into SA pathogenesis. We integrated data from the brain proteome (N = 376) and blood proteome (N = 35,559) and combined it with the largest SA GWAS summary statistics to date (N = 518,612). A comprehensive set of methods was employed, including Mendelian randomization (MR), Steiger filtering, Bayesian colocalization, proteome‑wide association studies (PWAS), transcript-levels, cell-type specificity, correlation, and protein-protein interaction (PPI) network analysis. Validation was performed using other protein datasets and the SA dataset from FinnGen study. We identifi

SUBMITTER: Zhao H 

PROVIDER: S-EPMC11224332 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature