CHI3L1 on fibrinolytic system imbalance in chronic rhinosinusitis with nasal polyp.

ABSTRACT:

Background

Chronic rhinosinusitis (CRS) is an inflammatory disease affecting more than 10% of the global adult population. It is classified into Th1, Th2, and Th17 endotypes and eosinophilic and non-eosinophilic types. Th2-based inflammation and eosinophilic CRS (ECRS) are associated with tissue remodeling and fibrinolytic system impairment.

Objective

To elucidate the role of eosinophils in inducing fibrin deposition in CRS nasal polyp tissues and explore potential regulatory mechanisms.

Methods

We analyzed the expression of genes related to the serpin family and fibrinolytic system using Gene Expression Omnibus and Next-generation sequencing data. Differentially expression genes (DEGs) analysis was used to compare control and nasal polyp tissues, followed by KEGG and

SUBMITTER: Yang HW 

PROVIDER: S-EPMC11224434 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature