Lrba participates in the differentiation of IgA+ B lymphocytes through TGFβR signaling.

ABSTRACT:

Introduction

Lrba is a cytoplasmic protein involved in vesicular trafficking. Lrba-deficient (Lrba-/-) mice exhibit substantially higher levels of IgA in both serum and feces than wild-type (WT) mice. Transforming growth factor β1 (TGFβ1) and its receptors (TGFβR I and II) is essential for differentiating IgA+ B cells. Furthermore, increased IgA production suggests a potential connection between Lrba and the TGFβR signaling pathway in IgA production. However, the specific function of Lrba in B cell biology remains unknown.

Aim

Given the increased IgA levels in Lrba-/- mice, the goal in this work was to explore the lymph organs where the switch to IgA occurs, and if TGFβR function is affected.

Methods

Non-immunized Lrba-/- mice were compared

SUBMITTER: Flores-Hermenegildo JM 

PROVIDER: S-EPMC11224471 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature