Connectome reorganization associated with temporal lobe pathology and its surgical resection.

ABSTRACT: Network neuroscience offers a unique framework to understand the organizational principles of the human brain. Despite recent progress, our understanding of how the brain is modulated by focal lesions remains incomplete. Resection of the temporal lobe is the most effective treatment to control seizures in pharmaco-resistant temporal lobe epilepsy (TLE), making this syndrome a powerful model to study lesional effects on network organization in young and middle-aged adults. Here, we assessed the downstream consequences of a focal lesion and its surgical resection on the brain's structural connectome, and explored how this reorganization relates to clinical variables at the individual patient level. We included adults with pharmaco-resistant TLE (n = 37) who underwent anterior temporal lobect

SUBMITTER: Lariviere S 

PROVIDER: S-EPMC11224603 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature