Adaptive coding of reward in schizophrenia, its change over time and relationship to apathy.

ABSTRACT: Adaptive coding of reward is the process by which neurons adapt their response to the context of available compensations. Higher rewards lead to a stronger brain response, but the increase of the response depends on the range of available rewards. A steeper increase is observed in a narrow range and a more gradual slope in a wider range. In schizophrenia, adaptive coding appears to be affected in different domains, especially in the reward domain. Here, we tested adaptive coding of reward in a large group of patients with schizophrenia (n = 86) and control subjects (n = 66). We assessed: (i) the association between adaptive coding deficits and symptoms; (ii) the longitudinal stability of deficits (the same task was performed 3 months apart); and (iii) the stability of results between two e

SUBMITTER: Kaliuzhna M 

PROVIDER: S-EPMC11224610 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature