Mendelian randomization highlights sleep disturbances mediated the effect of depression on chronic pain.

ABSTRACT:

Introduction

Depression and chronic pain are significant contributors to the global burden of disease. Previous research has revealed complex relationships between these two conditions, which may be influenced by sleep quality. However, observational studies have limitations, including confounding factors and reverse causation. This study aims to explore the mediating effects of sleep on the relationship between depression and chronic pain using Mendelian randomization (MR).

Methods

We conducted a two-step, two-sample MR study using mediation analysis. We obtained major depressive disorder (MDD) Genome-Wide Association Studdies (GWAS) data from Wray et al.'s GWAS meta-analysis. Phenotypic data related to sleep were collected from the UK Biobank. Chronic pain data were obtain

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC11224770 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature