Identifying the genetic association between common rheumatic diseases and vitiligo.

ABSTRACT:

Background

Although observational studies have suggested a correlation between vitiligo and rheumatic diseases, conclusive evidence supporting a causal relationship is still lacking. Therefore, this study aims to explore the potential causal relationship between vitiligo and rheumatic diseases.

Methods

Using genome-wide association studies, we performed a two-sample Mendelian randomization (MR) analysis. In our analysis, the random-effects inverse variance weighted (IVW) method was predominantly employed, followed by several sensitivity analyses, which include heterogeneity, horizontal pleiotropy, outliers, and "leave-one-out" analyses.

Results

The genetically predicted vitiligo was associated with an increased risk of rheumatoid arthritis (RA) (OR, 1.47; 95% confiden

SUBMITTER: Zhao M 

PROVIDER: S-EPMC11224917 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature