Genomic and phenotypic inconsistencies in Pseudomonas aeruginosa resistome among intensive care patients.

ABSTRACT:

Objective

Pseudomonas aeruginosa, a difficult-to-manage nosocomial pathogen, poses a serious threat to clinical outcomes in intensive care (ICU) patients due to its high antimicrobial resistance (AMR). To promote effective management, it is essential to investigate the genomic and phenotypic differences in AMR expression of the isolates.

Methods

A prospective observational study was conducted from July 2022 to April 2023 at Liepaja Regional Hospital in Latvia. The study included all adult patients who were admitted to the ICU and had a documented infection with P. aeruginosa, as confirmed by standard laboratory microbiological testing and short-read sequencing. Since ResFinder is the only sequencing-based database offering antibacterial susceptibility testing (

SUBMITTER: Dolgusevs M 

PROVIDER: S-EPMC11224958 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature