Numerical simulation study of nanoparticle diffusion in gray matter.

ABSTRACT:

Purpose

Nanomedicine-based approaches have shown great potential in the treatment of central nervous system diseases. However, the fate of nanoparticles (NPs) within the brain parenchyma has not received much attention. The complexity of the microstructure of the brain and the invisibility of NPs make it difficult to study NP transport within the grey matter. Moreover, regulation of NP delivery is not fully understood.

Methods

2D interstitial system (ISS) models reflecting actual extracellular space (ECS) were constructed. A particle tracing model was used to simulate the diffusion of the NPs. The effect of NP size on NP diffusion was studied using numerical simulations. The diffusion of charged NPs was explored by comparing experimental and numerical simulation data, and th

SUBMITTER: Chen P 

PROVIDER: S-EPMC11225016 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature