Reovirus infection induces transcriptome-wide unique A-to-I editing changes in the murine fibroblasts.

ABSTRACT: The conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans. In addition to its transcriptome-regulating role, ADARs also play a major part in immune response to viral infection, where an interferon response activates interferon-stimulated genes, such as ADARp150, in turn dynamically regulating host-virus interactions. A previous report has shown that infection from reoviruses, despite strong activation of ADARp150, does not influence the editing of some of the major known editing targets, while likely editing others, suggesting a potentially nuanced editing pattern that may depend on different factors. However, the result

SUBMITTER: Tariq A 

PROVIDER: S-EPMC11225029 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature