PSME3 promotes lung adenocarcinoma development by regulating the TGF-β/SMAD signaling pathway.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is one of the most common types of cancer worldwide. Proteasome activator subunit 3 (PSME3) is a subunit of a proteasome activator, and changes in PSME3 can lead to the development of many diseases in organisms. However, the specific mechanism of PSME3 in LUAD has not yet been elucidated. This study initially revealed the mechanism of PSME3 promoting the progression of lung adenocarcinoma, which provided a potential molecular target for clinical treatment.

Methods

PSME3 expression in LUAD cells and tissues was assessed by bioinformatics analysis, immunohistochemistry (IHC), Western blotting (WB), and quantitative real time polymerase chain reaction (qRT-PCR). A series of functional experiments were used to evaluate the effects of PSME3 k

SUBMITTER: Wang S 

PROVIDER: S-EPMC11225040 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature