Identification of a combined hypoxia and lactate metabolism prognostic signature in lung adenocarcinoma

ABSTRACT:

Background

In the tumor microenvironment (TME), a bidirectional relationship exists between hypoxia and lactate metabolism, with each component exerting a reciprocal influence on the other, forming an inextricable link. The aim of the present investigation was to develop a prognostic model by amalgamating genes associated with hypoxia and lactate metabolism. This model is intended to serve as a tool for predicting patient outcomes, including survival rates, the status of the immune microenvironment, and responsiveness to therapy in patients with lung adenocarcinoma (LUAD).

Methods

Transcriptomic sequencing data and patient clinical information specific to LUAD were obtained from comprehensive repositories of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). A

SUBMITTER: Sun J 

PROVIDER: S-EPMC11225160 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature