Contribution of copy number variants on antipsychotic treatment response in Han Chinese patients with schizophrenia.

ABSTRACT:

Background

Response to antipsychotic drugs (APD) varies greatly among individuals and is affected by genetic factors. This study aims to demonstrate genome-wide associations between copy number variants (CNVs) and response to APD in patients with schizophrenia.

Methods

A total of 3030 patients of Han Chinese ethnicity randomly received APD (aripiprazole, olanzapine, quetiapine, risperidone, ziprasidone, haloperidol and perphenazine) treatment for six weeks. This study is a secondary data analysis. Percentage change on the Positive and Negative Syndrome Scale (PANSS) reduction was used to assess APD efficacy, and more than 50% change was considered as APD response. Associations between CNV burden, gene set, CNV loci and CNV break-point and APD efficacy were analysed.

Findi

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11225184 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature