Comprehensive analysis and identification of subtypes and hub genes of high immune response in lung adenocarcinoma.

ABSTRACT:

Background

The advent of immunotherapy targeting immune checkpoints has conferred significant clinical advantages to patients with lung adenocarcinoma (LUAD); However, only a limited subset of patients exhibit responsiveness to this treatment. Consequently, there is an imperative need to stratify LUAD patients based on their response to immunotherapy and enhance the therapeutic efficacy of these treatments.

Methods

The differentially co-expressed genes associated with CD8 + T cells were identified through weighted gene co-expression network analysis (WGCNA) and the Search Tool for the Retrieval of Interacting Genes (STRING) database. These gene signatures facilitated consensus clustering for TCGA-LUAD and GEO cohorts, categorizing them into distinct immune subtypes (C1, C2,

SUBMITTER: Li H 

PROVIDER: S-EPMC11225283 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature