Potential association of rheumatic diseases with bone mineral density and fractures: a bi-directional mendelian randomization study.

ABSTRACT:

Background

Previous studies have implicated rheumatoid arthritis as an independent risk factor for bone density loss. However, whether there is a causal relationship between rheumatic diseases and bone mineral density (BMD) and fractures is still controversial. We employed a bidirectional Mendelian analysis to explore the causal relationship between rheumatic diseases and BMD or fractures.

Methods

The rheumatic diseases instrumental variables (IVs) were obtained from a large Genome-wide association study (GWAS) meta-analysis dataset of European descent. Analyses were performed for the three rheumatic diseases: ankylosing spondylitis (AS) (n = 22,647 cases, 99,962 single nucleotide polymorphisms [SNPs]), rheumatoid arthritis (RA) (n = 58,284 cases, 13,108,512 SNPs), and syste

SUBMITTER: Hong CX 

PROVIDER: S-EPMC11225327 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature