Artificial sweeteners and risk of incident cardiovascular disease and mortality: evidence from UK Biobank.

ABSTRACT:

Background

Artificial sweeteners are widely popular worldwide as substitutes for sugar or caloric sweeteners, but there are still several important unknowns and controversies regarding their associations with cardiovascular disease (CVD). We aimed to extensively assess the association and subgroup variability between artificial sweeteners and CVD and CVD mortality in the UK Biobank cohort, and further investigate the modification effects of genetic susceptibility and the mediation role of type 2 diabetes mellitus (T2DM).

Methods

This study included 133,285 participants in the UK Biobank who were free of CVD and diabetes at recruitment. Artificial sweetener intake was obtained from repeated 24-hour diet recalls. Cox proportional hazard models were used to estimate HRs. Geneti

SUBMITTER: Sun T 

PROVIDER: S-EPMC11225337 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature