DNA methylation of exercise-responsive genes differs between trained and untrained men.

ABSTRACT:

Background

Physical activity is well known for its multiple health benefits and although the knowledge of the underlying molecular mechanisms is increasing, our understanding of the role of epigenetics in long-term training adaptation remains incomplete. In this intervention study, we included individuals with a history of > 15 years of regular endurance or resistance training compared to age-matched untrained controls performing endurance or resistance exercise. We examined skeletal muscle DNA methylation of genes involved in key adaptation processes, including myogenesis, gene regulation, angiogenesis and metabolism.

Results

A greater number of differentially methylated regions and differentially expressed genes were identified when comparing the endurance group with the c

SUBMITTER: Geiger C 

PROVIDER: S-EPMC11225400 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature