Ethnic disparities in fracture risk assessment using polygenic scores.

ABSTRACT: Whether the PGS developed using data from European ancestry is predictive of fracture risk for minorities remains unclear. This study demonstrated that PGSs based on common BMD-related genetic variants discovered in the European ancestry cohort are predictive of fracture risk in people of Asian but not African ancestry.

Purpose

Large-scale genome-wide association studies (GWAS) on bone mineral density (BMD) have been conducted predominantly in European cohorts. Genetic models based on common variants associated with BMD have been evaluated using almost exclusively European data, which could potentially exacerbate health disparities due to different linkage disequilibrium among different ethnic groups.

Methods

UK Biobank (UKB) is a large-scale population-based observational st

SUBMITTER: Xiao X 

PROVIDER: S-EPMC11225529 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature