Increased whole-brain functional heterogeneity in psychosis during rest and task.

ABSTRACT: Past work has shown that people with schizophrenia exhibit more cross-subject heterogeneity in their functional connectivity patterns. However, it remains unclear whether specific brain networks are implicated, whether common confounds could explain the results, or whether task activations might also be more heterogeneous. Unambiguously establishing the existence and extent of functional heterogeneity constitutes a first step toward understanding why it emerges and what it means clinically.

Methods

We first leveraged data from the HCP Early Psychosis project. Functional connectivity (FC) was extracted from 718 parcels via principal components regression. Networks were defined via a brain network partition (Ji et al., 2019). We also examined an independent data set with controls, lat

SUBMITTER: Keane BP 

PROVIDER: S-EPMC11225660 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature