Sarbecovirus disease susceptibility is conserved across viral and host models.

ABSTRACT: Coronaviruses have caused three severe epidemics since the start of the 21^st century: SARS, MERS and COVID-19. The severity of the ongoing COVID-19 pandemic and increasing likelihood of future coronavirus outbreaks motivates greater understanding of factors leading to severe coronavirus disease. We screened ten strains from the Collaborative Cross mouse genetic reference panel and identified strains CC006/TauUnc (CC006) and CC044/Unc (CC044) as coronavirus-susceptible and resistant, respectively, as indicated by variable weight loss and lung congestion scores four days post-infection. We generated a genetic mapping population of 755 CC006xCC044 F2 mice and exposed the mice to one of three genetically distinct mouse-adapted coronaviruses: clade 1a SARS-CoV MA15 (n=391), clade 1b

SUBMITTER: Leist SR 

PROVIDER: S-EPMC11225686 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature