Brain microstructure and connectivity in COVID-19 patients with olfactory or cognitive impairment.

ABSTRACT:

Introduction

The COVID-19 pandemic has affected millions worldwide, causing mortality and multi-organ morbidity. Neurological complications have been recognized. This study aimed to assess brain structural, microstructural, and connectivity alterations in patients with COVID-19-related olfactory or cognitive impairment using post-acute (time from onset: 264[208-313] days) multi-directional diffusion-weighted MRI (DW-MRI).

Methods

The study included 16 COVID-19 patients with cognitive impairment (COVID-CM), 35 COVID-19 patients with olfactory disorder (COVID-OD), and 14 controls. A state-of-the-art processing pipeline was developed for DW-MRI pre-processing, mean diffusivity and fractional anisotropy computation, fiber density and cross-section analysis, and tractography of w

SUBMITTER: Arrigoni A 

PROVIDER: S-EPMC11225694 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature