Ventilator-induced Lung Injury Promotes Inflammation within the Pleural Cavity.

ABSTRACT: Mechanical ventilation contributes to the morbidity and mortality of patients in intensive care, likely through the exacerbation and dissemination of inflammation. Despite the proximity of the pleural cavity to the lungs and exposure to physical forces, little attention has been paid to its potential as an inflammatory source during ventilation. Here, we investigate the pleural cavity as a novel site of inflammation during ventilator-induced lung injury. Mice were subjected to low or high tidal volume ventilation strategies for up to 3 hours. Ventilation with a high tidal volume significantly increased cytokine and total protein levels in BAL and pleural lavage fluid. In contrast, acid aspiration, explored as an alternative model of injury, only promoted intraalveolar inflammation, with no

SUBMITTER: Baldi RF 

PROVIDER: S-EPMC11225872 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature