Upregulation of tyrosine kinase TKT by the Epstein-Barr virus transactivator Zta.

ABSTRACT: The Zta protein is a key transactivator involved in initiating the Epstein-Barr virus (EBV) lytic cascade. In addition to transactivating many viral genes, Zta has the capacity to influence host cellular signals by binding to promoter regions or by interacting with several important cellular factors. Based on the observation that tyrosine kinases play central roles in determining the fate of cells, a kinase display assay was used to investigate whether cells expressing Zta have an altered pattern of kinase expression. The assay revealed that TRK-related tyrosine kinase (TKT) is expressed at significant levels in Zta transfectants but not in control cells. Additional evidence was obtained from Northern and Western blotting. Importantly, the upregulation of phosphorylated TKT and TKT downstr

SUBMITTER: Lu J 

PROVIDER: S-EPMC112259 | biostudies-literature | 2000 Aug

REPOSITORIES: biostudies-literature