Betaine and I-LG may have a predictive value for ATB: A causal study in a large European population.

ABSTRACT:

Purpose

To analyze the causal relationship between 486 human serum metabolites and the active tuberculosis (ATB) in European population.

Methods

In this study, the causal relationship between human serum metabolites and the ATB was analyzed by integrating the genome-wide association study (GWAS). The 486 human serum metabolites were used as the exposure variable, three different ATB GWAS databases in the European population were set as outcome variables, and single nucleotide polymorphisms were used as instrumental variables for Mendelian Randomization. The inverse variance weighting was estimated causality, the MR-Egger intercept to estimate horizontal pleiotropy, and the combined effects of metabolites were also considered in the meta-analysis. Furthermore, the web-based M

SUBMITTER: Xian X 

PROVIDER: S-EPMC11226055 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature