Phenome-wide association study identifies new clinical phenotypes associated with Staphylococcus aureus infections.

ABSTRACT:

Background

Phenome-Wide Association study (PheWAS) is a powerful tool designed to systematically screen clinical observations derived from medical records (phenotypes) for association with a variable of interest. Despite their usefulness, no systematic screening of phenotypes associated with Staphylococcus aureus infections (SAIs) has been done leaving potential novel risk factors or complications undiscovered.

Method and cohorts

We tailored the PheWAS approach into a two-stage screening procedure to identify novel phenotypes correlating with SAIs. The first stage screened for co-occurrence of SAIs with other phenotypes within medical records. In the second stage, significant findings were examined for the correlations between their age of onset with that of SAIs. The PheWAS

SUBMITTER: Allaire P 

PROVIDER: S-EPMC11226111 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature