Immunosuppression in stem cell clinical trials of neural and retinal cell types: A systematic review.

ABSTRACT:

Background

Pharmacologic immunosuppression regimes are commonly employed in stem cell clinical trials to mitigate host immune rejection and promote survival and viability of transplanted cells. Immunosuppression and cell survival has been extensively studied in retinal and spinal tissues. The applicability of stem cell therapy is rapidly expanding to other sensory organs such as the ear and hearing. As regenerative therapy is directed to new areas, a greater understanding of immunosuppression strategies and their efficacy is required to facilitate translation to organ-specific biologic microenvironments.

Objective

This systematic review appraises the current literature regarding immunosuppression strategies employed in stem cell trials of retinal and neural cells.

Methods

SUBMITTER: Gowrishankar S 

PROVIDER: S-EPMC11226136 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature