28 NICUs participating in a quality improvement collaborative targeting early-onset sepsis antibiotic use.

ABSTRACT:

Objective

There is widespread overuse of antibiotics in neonatal intensive care units (NICUs). The objective of this study was to safely reduce antibiotic use in participating NICUs by targeting early-onset sepsis (EOS) management.

Study design

Twenty-eight NICUs participated in this statewide multicenter antibiotic stewardship quality improvement collaborative. The primary aim was to reduce the total monthly mean antibiotic utilization rate (AUR) by 25% in participant NICUs.

Result

Aggregate AUR was reduced by 15.3% (p < 0.001). There was a wide range in improvement among participant NICUs. There were no increases in EOS rates or nosocomial infection rates related to the intervention.

Conclusion

Participation in this multicenter NICU antibiotic stewardship col

SUBMITTER: Payton KSE 

PROVIDER: S-EPMC11226396 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature