E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer.

ABSTRACT: Human papillomaviruses (HPV) are a major cause of malignancy, contributing to ~5% of all human cancers worldwide, including most cervical cancer cases and a growing number of anogenital and oral cancers. The major HPV viral oncogenes, E6 and E7, manipulate many host cellular pathways that promote cell proliferation and survival, predisposing infected cells to malignant transformation. Despite the availability of highly effective vaccines, there are still no specific anti-viral therapies targeting HPV or treatments for HPV-associated cancers. As such, a better understanding of viral-host interactions may allow the identification of novel therapeutic targets. Here, we demonstrate that the actin-binding protein LASP1 is upregulated in cervical cancer and significantly correlates with a poorer

SUBMITTER: Patterson MR 

PROVIDER: S-EPMC11226402 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature