Causal relationship and shared genes between air pollutants and amyotrophic lateral sclerosis: A large-scale genetic analysis.

ABSTRACT:

Objective

Air pollutants have been reported to have a potential relationship with amyotrophic lateral sclerosis (ALS). The causality and underlying mechanism remained unknown despite several existing observational studies. We aimed to investigate the potential causality between air pollutants (PM2.5, NO_X, and NO₂) and the risk of ALS and elucidate the underlying mechanisms associated with this relationship.

Methods

The data utilized in our study were obtained from publicly available genome-wide association study data sets, in which single nucleotide polymorphisms (SNPs) were employed as the instrumental variantswith three principles. Two-sample Mendelian randomization and transcriptome-wide association (TWAS) analyses were conducted to evaluate the effe

SUBMITTER: Li Z 

PROVIDER: S-EPMC11226412 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature