Analysis of clinical characteristics of mismatch repair status in colorectal cancer: a multicenter retrospective study.

ABSTRACT:

Background

Microsatellite instability (MSI) caused by DNA mismatch repair (MMR) deficiency is of great significance in the occurrence, diagnosis and treatment of colorectal cancer (CRC).

Aim

This study aimed to analyze the relationship between mismatch repair status and clinical characteristics of CRC.

Methods

The histopathological results and clinical characteristics of 2029 patients who suffered from CRC and underwent surgery at two centers from 2018 to 2020 were determined. After screening the importance of clinical characteristics through machine learning algorithms, the patients were divided into deficient mismatch repair (dMMR) and proficient mismatch repair (pMMR) groups based on the immunohistochemistry results and the clinical feature data between the two gro

SUBMITTER: Mao J 

PROVIDER: S-EPMC11226506 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature