Alteration of β-glucan in the emerging fungal pathogen Candida auris leads to immune evasion and increased virulence.

ABSTRACT: Candida auris is an emerging pathogenic yeast that has been categorized as a global public health threat and a critical priority among fungal pathogens. Despite this, the immune response against C. auris infection is still not well understood. Hosts fight Candida infections through the immune system that recognizes pathogen-associated molecular patterns such as β-glucan, mannan, and chitin on the fungal cell wall. In this study, levels of β-glucan and mannan exposures in C. auris grown under different physiologically relevant stimuli were quantified by flow cytometry-based analysis. Lactate, hypoxia, and sublethal concentration of fluconazole trigger a decrease in surface β-glucan while low pH triggers an increase in β-glucan. There is no inverse pattern between exposure levels of β-glucan

SUBMITTER: Selisana SMG 

PROVIDER: S-EPMC11226559 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature