Low-dose ionizing radiation generates a hormetic response to modify lipid metabolism in Chlorella sorokiniana.

ABSTRACT: Algal biomass is a viable source of chemicals and metabolites for various energy, nutritional, medicinal and agricultural uses. While stresses have commonly been used to induce metabolite accumulation in microalgae in attempts to enhance high-value product yields, this is often very detrimental to growth. Therefore, understanding how to modify metabolism without deleterious consequences is highly beneficial. We demonstrate that low-doses (1-5 Gy) of ionizing radiation in the X-ray range induces a non-toxic, hormetic response in microalgae to promote metabolic activation. We identify specific radiation exposure parameters that give reproducible metabolic responses in Chlorella sorokiniana caused by transcriptional changes. This includes up-regulation of >30 lipid metabolism genes, such as g

SUBMITTER: Stanic M 

PROVIDER: S-EPMC11226653 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature