A shape-driven reentrant jamming transition in confluent monolayers of synthetic cell-mimics.

ABSTRACT: Many critical biological processes, like wound healing, require densely packed cell monolayers/tissues to transition from a jammed solid-like to a fluid-like state. Although numerical studies anticipate changes in the cell shape alone can lead to unjamming, experimental support for this prediction is not definitive because, in living systems, fluidization due to density changes cannot be ruled out. Additionally, a cell's ability to modulate its motility only compounds difficulties since even in assemblies of rigid active particles, changing the nature of self-propulsion has non-trivial effects on the dynamics. Here, we design and assemble a monolayer of synthetic cell-mimics and examine their collective behaviour. By systematically increasing the persistence time of self-propulsion, we dis

SUBMITTER: Arora P 

PROVIDER: S-EPMC11226658 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature