Steven Tarquin Goulding
Ontology highlight
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PROVIDER: S-EPMC1122668 | biostudies-literature | 2002 Mar
REPOSITORIES: biostudies-literature
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Project description: Not available
| S-EPMC1124825 | biostudies-literature
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| S-EPMC1126349 | biostudies-literature
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| S-EPMC6835054 | biostudies-literature
Project description:There are so many compliments to Dr. Steven Lindauer that is hard for one to figure where to start from… Well, travelling backwards in time, all the way to the year 2000, I went to Virginia to study English at Virginia Commonwealth University (VCU), in Richmond, Virginia, USA. During my daily walks to the English school, I used to pass by the School of Dentistry, where the Department of Orthodontics was. That was the place where my very first "contact" with the VCU happened. In 2015, 15 years later, I had the pleasure to go back to the VCU and spend two days with Dr. Steven Lindauer. I have to confess that I was anxious and nervous to get to know not only the Chair of the Department, but also the Editor-in-chief of "The Angle Orthodontist". Since the very first moment I could experience how incredibly positive and pro-active the environment within the Department was. Staff members, Residents and Faculty members used to work very gladly and in perfect synergy. After a quick chat with the residents, I heard from them: "Dr. Lindauer is an unprecedented human being! Besides a brilliant Professor, Researcher and Administrator, he is like a father to all of us!" Besides this touching testimony, I also heard flattering compliments from workmates to the great friend, leader and partner Dr. Lindauer was. Here goes some food for thought, though. Unfortunately, the leader is often compelled to resort to unpopular measures in order to enforce compliance. Dr Lindauer is the living proof that a boss, a leader, can be a light, humble, friendly and highly charismatic human being. In 2016, I was given a second chance to enjoy Dr. Lindauer's company when he visited Brazil as a guest lecturer in Salvador, at the Federal University of Bahia and the Brazilian Association of Orthodontics (Bahia Chapter). I noticed, once again, that besides an excellent lecturer and careful clinician, he mastered orthodontic mechanics very proficiently. And needless to say at length about his brilliance ahead of "The Angle Orthodontist"... It didn't take me long to realize that his virtues by far exceeded the boundaries of the professional domain. Despite his utterly busy schedule, he is still able to dedicate time to his parents, taking them to trips around the world. Interestingly, at every international trip, he always remembers his puppies (Memphis, Baxter and Kingston - in memoriam), taking sightseeing pictures to immediately Photoshop them into. Having done the well deserved introductions to our distinguished interviewee, I would like to offer righteous acknowledgements to the colleagues Jorge Faber, David Turpin, Bhavna Shroff and David Normando, for having accepted the invitation to take part in this interview. I also would like to offer my heartfelt thanks to Dental Press for having entrusted me with the honor to conduct this project. I wish all readers as delightful and rich of an experience when going through this interview as it's been the scientific path that brought us all here in the first place. No doubts, you stand in face of a life dedicated to Orthodontics. (Andre Wilson Machado, interview coordinator).
| S-EPMC5525443 | biostudies-other
Project description:IntroductionStevens Jonson syndrome, a type IV mediated hypersensitivity reaction is a rare mucocutaneous disorder accounting for <10% of TBSA. It affects skin, oral mucosa, eyes, esophagus, mouth, pharynx, larynx, skin and genitals. SJS is caused mainly due to drugs, infectious agents, immunization, and radiation therapy.Presentation of caseWe present a case of a 40 years old male who developed SJS after being administered cefixime for a short period. Given the patient's past profile, he was admitted due to RTA and was under treatment with cefixime. Irrespective of any symptoms of SJS in the past, he started developing symptoms soon after being treated with cefixime giving us a clue about cefixime-induced SJS.DiscussionSteven-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are opposite ends of a spectrum of diseases arising usually from an adverse reaction to medications. The most common drug reactions include penicillin in antibiotics, carbamazepine in antiepileptics and allopurinol in gout treatment in the Asian community. In our case, the patient was under Cefixime for 6 days after which cutaneous manifestations were seen. SJS is a fatal condition, with a global mortality rate stretching between 10% and 34%. The first step in its management is to identify the culprit drug and stop its use. Other is symptomatic, with special attention to airway and hemodynamic stability, wound care, and pain alleviation measures. Medical therapy include corticosteroids, cyclosporine, intravenous immunoglobulin (IVIG), and TNF- α inhibitors.ConclusionCephalosporin group, like cefixime, is a commonly prescribed drug in developing countries due to its efficacy and cost-effectiveness. Therefore, physicians must beforehand be mindful of the consequences of its use and advice patients to visit the hospital with even the slightest cutaneous manifestation.
| S-EPMC9289488 | biostudies-literature
Project description:Single nucleotide polymorphism (SNP) markers are powerful tools for investigating population structures, linkage analysis, and genome-wide association studies, as well as for breeding and population management. The availability of SNP markers has been limited to the most commercially important timber species, primarily due to the cost of genome sequencing required for SNP discovery. In this study, a combination of reference-based and reference-free approaches were used to identify SNPs in Nordmann fir (Abies nordmanniana), a species previously lacking genomic sequence information. Using a combination of a genome assembly of the closely related Silver fir (Abies alba) species and a de novo assembly of low-copy regions of the Nordmann fir genome, we identified a high density of reliable SNPs. Reference-based approaches identified two million SNPs in common between the Silver fir genome and low-copy regions of Nordmann fir. A combination of one reference-free and two reference-based approaches identified 250 shared SNPs. A subset of 200 SNPs were used to genotype 342 individuals and thereby tested and validated in the context of identity analysis and/or clone identification. The tested SNPs successfully identified all ramets per clone and five mislabeled individuals via identity and genomic relatedness analysis. The identified SNPs will be used in ad hoc breeding of Nordmann fir in Denmark.
| S-EPMC10728141 | biostudies-literature
Project description:Methazolamide is used to treat patients with glaucoma. However, as a sulfonamide derivative, methazolamide shares the same adverse reaction profile as other sulfa-based medications. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare delayed-type hypersensitivity cutaneous reactions with high morbidity and mortality. Here, we report a severe SJS/TEN overlap syndrome in an 85-year-old Chinese male patient who received methazolamide 25 mg twice daily for his left eye glaucoma. The causal relationship between SJS/TEN and methazolamide was categorized as "highly likely" on the algorithm for assessing drug causality for epidermal necrolysis. In addition to the treatments with methylprednisolone and immunoglobulin, we used a special electromagnetic spectrum therapeutic apparatus to provide skin wound care. The patient had a thoroughly satisfying recovery. This is the first case report to use electromagnetic field therapy in a patient with SJS/TEN. We share our experience here and suggest that electromagnetic field therapy can provide advanced skin wound care and facilitate the recovery of SJS/TEN.
| S-EPMC10248229 | biostudies-literature
Project description: Not available
2017-01-20 | LDS-1370 | LINCS