Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals.

ABSTRACT: The mechanisms through which obesity impacts age-related muscle mass regulation are unclear. In the present study, rates of integrated myofibrillar protein synthesis (iMyoPS) were measured over 48-h prior-to and following a 45-min treadmill walk in 10 older-obese (O-OB, body fat[%]: 33 ± 3%), 10 older-non-obese (O-NO, 20 ± 3%), and 15 younger-non-obese (Y-NO, 13 ± 5%) individuals. Surface electromyography was used to determine thigh muscle "activation". Quadriceps cross-sectional area (CSA), volume, and intramuscular thigh fat fraction (ITFF) were measured by magnetic resonance imaging. Quadriceps maximal voluntary contraction (MVC) was measured by dynamometry. Quadriceps CSA and volume were greater (muscle volume, Y-NO: 1182 ± 232 cm³; O-NO: 869 ± 155 cm³; O-OB: 881 

SUBMITTER: Morgan PT 

PROVIDER: S-EPMC11226697 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature