Dataset of DNA methylation profiles of 189 pediatric central nervous system, soft tissue, and bone tumors.

ABSTRACT: Alterations in DNA methylation profiles belong to important mechanisms in cancer development, and their assessment can be utilized for rapid and precise diagnostics. Therefore, establishing datasets of methylation profiles can improve and deepen our understanding of the role of epigenetic changes in cancer development as well as improve our diagnostic capabilities. In this dataset, we generated NGS data for 189 samples of pediatric CNS, soft tissue, and bone tumors. The sequencing libraries were prepared using methyl capture bisulfite sequencing, an effective compromise between whole-genome bisulfite sequencing and array-based methods with a more limited scope of target regions. The larger part of the cohort was processed with the Agilent SureSelectXT Human Methyl-Seq kit (149 samples) and

SUBMITTER: Jugas R 

PROVIDER: S-EPMC11226799 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature